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Advanced Member
Group: Advanced Members
Posts: 428
Member No.: 41194
Joined: 30-August 04
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yeah aniracetam make feel sleepy . piracetam works a lot beter on me ? why ? aniracetam is suposed to be more potent than piracetam . what is wrong with my brain ? Actualy i took it before bed.
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Aniracetam is not just simply an analogue of piracetam modifed to escape a patent - for one piracetam is not even covered by a patent anymore. One basic fact of smart drug usage I don't see mentioned at all on these boards is this: If you are using any 'cetam, you MUST use a choline supplement as the increased neural activty will slowly deplete your brain's endogenous acetylcholine levels. If 'cetams are giving you nasty headaches or making you dopey feeling, this is a very good indicator of AcH depletion. The easiest and cheapest way to supplement choline levels is to take some lecihtin granules with your morning protein shake (I also find that flax oil taken in the morning helps immensely with mental clarity). Beware of cheap choline bitartate tablets - very little choline survives the first intestinal pass as this substance has a very low bioavailablity. Lecithin is the most bioavailable form of choline and is good for your cholesterol levels.
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Advanced Member
Group: Advanced Members
Posts: 428
Member No.: 41194
Joined: 30-August 04
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| QUOTE (Charles59545 @ Jan 20 2005, 05:26 PM) | Aniracetam is not just simply an analogue of piracetam modifed to escape a patent - for one piracetam is not even covered by a patent anymore.
One basic fact of smart drug usage I don't see mentioned at all on these boards is this: If you are using any 'cetam, you MUST use a choline supplement as the increased neural activty will slowly deplete your brain's endogenous acetylcholine levels. If 'cetams are giving you nasty headaches or making you dopey feeling, this is a very good indicator of AcH depletion. The easiest and cheapest way to supplement choline levels is to take some lecihtin granules with your morning protein shake (I also find that flax oil taken in the morning helps immensely with mental clarity). Beware of cheap choline bitartate tablets - very little choline survives the first intestinal pass as this substance has a very low bioavailablity. Lecithin is the most bioavailable form of choline and is good for your cholesterol levels. |
1)u didnt understood me. 2)and why if aniracetam isnt related to piracetam ? while they clain him to be 3x more potent a patented substance alow the corp to manufacture it and gain $$$. and generic maker had to wait for the patent to END befor geting into the market !!!!!!!!!!!!!!!!!!!!!!!!!!!!! the pharma-corp who discovered the piracetam is caled UCB and has lost a lot of money when the patent ended. because generic maker manufacture it for cheaper. So guess what ?: do u think that a such big corp will not figth 4 avoding this lost of money (in millions $$$) ? 
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I am a big fan of nootropics, as I take Huperzine A, Ginkgo Biloba, Vinpocetine, ALCAR, L-Tyrosine, some DMAE, and Anricetam...with EXCELLENT results. Having said that, what do you guys think about Biotest's new nootropic called Spike? Here is some info. on it: Supplement Facts Serving Size: 1 Capsule Servings Per Container: 60 SPIKE™ Formula 350 mg * T-MAX™ (thiamine disulfide diisobutyrate), caffeine, lauroyl macrogol-32 glycerides I ran a search for the ingredients on pubmed and other sites, but no hits.
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Advanced Member
Group: Advanced Members
Posts: 428
Member No.: 41194
Joined: 30-August 04
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| QUOTE (Eric50906 @ Jan 22 2005, 09:16 AM) | I am a big fan of nootropics, as I take Huperzine A, Ginkgo Biloba, Vinpocetine, ALCAR, L-Tyrosine, some DMAE, and Anricetam...with EXCELLENT results.
Having said that, what do you guys think about Biotest's new nootropic called Spike? Here is some info. on it:
Supplement Facts
Serving Size: 1 Capsule Servings Per Container: 60
SPIKE™ Formula 350 mg *
T-MAX™ (thiamine disulfide diisobutyrate), caffeine, lauroyl macrogol-32 glycerides
I ran a search for the ingredients on pubmed and other sites, but no hits. |
whamo  all we know about u is u juste have one post at the time u wrote this !
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[QUOTE=Saber41194,Jan 14 2005, 06:50 PM] yeah aniracetam make feel sleepy . piracetam works a lot beter on me ? why ? aniracetam is suposed to be more potent than piracetam . what is wrong with my brain ? Actualy i took it before bed. ---------------------- Aniracetam uses up the choline in your brain. If you don't take it with a choline supplement it will definitely make you tired after a few days! I take it with Alpha GPC, but you could use centrophenoxine or phosphatidyl choline. The first two work a LOT faster than phosphatidyl choline, plain choline, lecithin, etc.. 
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Hello Guys and gals,<br>I have a question in which I am seeking answers for and believe that the members of this forum will be able to assist me with great efficiency. I have been taking Ginkoba and 5HTP for 4 years now.(Ginkoba 3 x a day and 5HTP 1 before bed) with stellar results. I recently just ordered the following supplements: <br>- Alpha GPC<br>
- Omega3<br>
- UN Centrophenoxine 500mg<br>
- UN Idebenone 90mg<br>
- UN Piracetam 800mg<br>
<br>Now my main question is this: is it safe to be taking the recommended dosage of all the above supplements along with the Ginkoba and 5HTP that I have been taking? Are there any possible side affects? I would like to hear the advice from the members of this forum. Please note that I do not exercise as much as I should be and work as an engineer so I really need to be able to focus and have the creativity that my job requires, yet without the harmful and down affects of caffeine. <br>TIA,<br>ED <br>
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| QUOTE (Saber41194 @ Jan 14 2005, 06:50 PM) | yeah aniracetam make feel sleepy . piracetam works a lot beter on me ? why ? aniracetam is suposed to be more potent than piracetam .
what is wrong with my brain ? Actualy i took it before bed. |
Taking choline at 500mg thrice daily should negate any drowsiness from racetams.
Avant Research Representative
Colin@AvantResearch.com
AvantResearch.com
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Hi, I have been taking Aniracetam for a week and, although the first 3 days of taking it were amazing, it has started to wear off early and causes dopeyness and lethargy. From reading previous posts I am assuming this must be because the Aniracetam is depleting my acetylcholine levels so I need to take a choline supplament to keep the levels up. I have tried co-administering DMAE along side the Ani but it has had no real helpfull effect yet. I may need to experiment with the dose. Also,how is Aniracetam supposed to be taken? I have seen information stating that the therapeutic effects dont start to be noticed till after 60 days! but this wasnt mentioned when I bought the product. This could explain why it is wearing off after a week as there has not been enough time for it to build up in my system?
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| QUOTE (danny82 @ Apr 20 2008, 05:51 PM) | Hi, I have been taking Aniracetam for a week and, although the first 3 days of taking it were amazing, it has started to wear off early and causes dopeyness and lethargy. From reading previous posts I am assuming this must be because the Aniracetam is depleting my acetylcholine levels so I need to take a choline supplament to keep the levels up. I have tried co-administering DMAE along side the Ani but it has had no real helpfull effect yet. I may need to experiment with the dose.
Also,how is Aniracetam supposed to be taken? I have seen information stating that the therapeutic effects dont start to be noticed till after 60 days! but this wasnt mentioned when I bought the product. This could explain why it is wearing off after a week as there has not been enough time for it to build up in my system? |
Although it is a lipophilic molecule, Aniracetam will NOT build up in your system. The half-life of aniracetam is around 2 hours. Also the idea that it takes 60 days for a theraputic effect is nonsense. Aniracetam has immediate effects on cognition, as displayed experimentally in a WMS test and various other tests on rats. Similarly, the effects immediately disappear after cessation. There are no long lasting observable effects (as displayed by rats with TBI treated with aniracetam). Remember that Aniracetam is a very weak ampakine, and barely affects AMPA-->NMDA-->BDNF mRNA-->trkB upregulation. With that said, the idea that it could deplete choline is probably a far fetched assumption NOT based on empirical evidence. Thats not to say that a more BBB-transductable Ach source wouldn't be a good idea, however. Ultimately, Aniracetam has been proven to improve cognition immediately in models of tramatic brain injury and dementia, but at the same time has not been proven to improve cognition in healthy participants. In theory, if you are planning to use Aniracetam as a cognition-enhancer, you should use upwards of 1200mg/day, spread out as far as possible throughout the day. Most imporantly however, is to stay away from GABAnergic agonists, and keep your brain active. Any other questions?
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Thank you for your very insightful response to my question about how to take Aniracetam. Its true that the best dose is upwards of 1200mg as i need to take two 750mg tabs to get a noticeable effect. Taking DMAE between doeses does seem to decrease the drowsiness as the ani wears off however this could be mainly due to placebo effect as i feel an improvement almost at the same moment as i swallow the tab. I do have a question however about what a BBB-transductable acetylcholine source would be? and I guess that Alcohol would be an example of a GABAergic agonist? I find alcohol to reduce the effects of alcohol intoxication which i find can be advantageous in certain situations.
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| QUOTE (danny82 @ May 6 2008, 06:39 PM) | Thank you for your very insightful response to my question about how to take Aniracetam. Its true that the best dose is upwards of 1200mg as i need to take two 750mg tabs to get a noticeable effect. Taking DMAE between doeses does seem to decrease the drowsiness as the ani wears off however this could be mainly due to placebo effect as i feel an improvement almost at the same moment as i swallow the tab.
I do have a question however about what a BBB-transductable acetylcholine source would be? and I guess that Alcohol would be an example of a GABAergic agonist? I find alcohol to reduce the effects of alcohol intoxication which i find can be advantageous in certain situations. |
In actuality, aniracetam directly stimulates the CNS. This is more strongly evident in one of its analogues: phenylpiracetam. Personally, I've taken well over 3 grams of aniracetam at one sitting and its feel is similar to <100mg of caffeine. To address your questions: probably the most BBB transductable form of Ach is Alpha-GPC. Similarly, a mild Ach-esterase inhibitor like Huperzine might have some benefit. And yes, alcohol would be a GABAergic agonist, in addition to phenibut, and a few other supplements on this site (lemon balm). Prescription forms abound including benzo's, some antipsychotics, exc.
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Hi the diesel. You state that aniracetam directly stimulates the CNS, but drugs like amphetamine that do this and are illegal. Am I right in thinking that amphetamine works by producing an increase in the amount of neurotransmitters in the synapse where as Aniracetam only amplifies the signals that are already being produced naturally? you mentioned that Alpha-GPC is the bset BBB transductable form of Ach, and as it happens i had already ordered some, so i guess i did my research well there. Have you had any experiences with Phenylpiracetam or any of the other racetams at all?
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aniracetam, make me feel sleepy
