In my opinion... you don't need NO2. Or glutamine.

However, according to the research I've seen at least, glutamine would have the potential to negate the effect, by blunting eNOS activity. Not sure how significant this effect is though.

Assuming the products are effective at increasing NO, it will cause vasodilation which will make your veins pop out, but this doesn't necessarily equate to a real increase in size/strength.

I truly think that I am one of the few people that got some pretty good results from taking NO type prods for about a year. Essentially, my base weight went up about 10 lbs with minimal inc in bfat (infact, waist line looked a bit leaner). I think that subjective effects from the NO prods are just that, subjective from person to person. However, the vast majority of people seem to have had poor results. I am interested in the new citrulline based prods like Syntrax's Nitrous, but only time will tell....

A couple of labs are attempting to figure out the role of NO in skeletal muscle hypertrophy. That's not to say that ingesting NO precursors will have any ergogenic effect upon that hypertrophy but hypertrophy and NOS expression/activity definately seem show some correlation. Dr. Tidball's lab seem to have done a bit more than Dr. Criswell on the subject but Dr. Criswell should have submitted another article by now, I think (saw him talk a lil while ago). Dr. Criswell's article has a few decent links to NO/hypertrophy articles and Dr. Tidball's is a bit newer for more recent stuff.

Again, while they may be correlated, it's yet to be proven that administration of NO precursors, which are also used in the simple removal of ammonia during workouts, will definatively produce any ergogenic effects (at least, to the best of my knowledge...feel free to correct me ).

Involvement of nitric oxide synthase in skeletal muscle adaptation to chronic overload.

Expression of a muscle-specific, nitric oxide synthase transgene prevents muscle membrane injury and reduces muscle inflammation during modified muscle use in mice.

The problem is, even after all the signalling mechanisms are figured out, it will still not be clear if the product will actually function, in vivo, as it does in theory - so I think it is best to remain skeptical until results are shown in a clinical study in the appropriate population (resistance training humans).

*nods* I was merely pointing out that NOS may have some function other than vasodialation during hypertrophy, not that there is necessarily any benefit from oral NO precursor administration. I am, by no means, a fanboi of NO products

what have you heard about no2? I am planning on taking some I am just wondering if it is gonna hurt me in someway or is it gonna be beneficial to me? could you or someone email me at melanson104@hotmail.com with some kind of information on what I should expect if I do take this stuff.