LeptiGen for Larger People

Bump.


But, since I can kind of estimate where the person is going to fall once you give an answer, no, at this time, I think you would do best to save the Leptigen until this person is somewhat leaner & has been dieting for some time.

The basic gist as that-- at higher bodyfat levels-- the obesity condition is-- if anything-- actually 'exacerbated' by leptin, because the body's signalling system (especially certain key receptors in the brain) becomes 'numbed' in effect to leptin. You eat; glucose goes through the HPB; insulin becomes elevated, etc.-- but the brain doesn't catch on that it's 'fed' and should stop eating. This is known as 'Leptin Resistance,' and Leptigen should never be used by such individuals, because how it works (via using end/byproducts & stimulating receptors to signal that the body is being fed & a starvation response is unnecessary) won't improve things any in this state.

Now, I cannot say with certainty that the individual you speak of actually is leptin resistant, but the idea is that leptin is an anti-starvation hormone, and only functions as a hormonal/homeostatic regulator when the body distinctly feels there is a shortage that it needs to respond to. Someone who is just getting back into exercising & dieting is not sending any such sort of signal, which is why the Leptigen should be saved until said person's new routine 'stalls' and they find further weight loss is becoming difficult.

Finally, Par & Avant, who I'm currently working for, will be releasing a specialized Leptigen specifically intended for people who are heavier &/or perhaps Leptin resistant to whatever degree, which-- when available-- would be a better choice for this person you speak of. Last I heard, this product is due to be available by early summer @ the latest, if not sooner.

I'm interested to hear if this version of Leptigen will have a larger female target audience.

- Fletch

Bump on that. It's not a diss on the ladies either; Women simply carry more bodyfat than men.

Who says you have to be a mod to answer a question?

I have a rep that is hard to get rid of

Yes David, but generally, in the obese you WANT a drop in leptin levels, because it negates the resistance and actually causes several of the brain's leptin receptors to upregulate in response to the decreased glucose flow through the adipocytes/HPB.

Initially, this will only have positive effects on CRH/NPY (PYY) regulation, because leptin sensitivity will easily compensate for the initial decline, assuming the person is fairly heavy, doesn't just start blatantly starving themselves, and has yet to seriously diet (which is why you'll notice that for heavier dieters, once they get their shit together, fat loss proceeds quite quickly even while--at times-- LBM is gained/preserved indisputably).

I really don't want to come off pretentious in regards to leptin, but it really is one of the few subjects I actually feel I have a decent understanding of, and one of the things that's clear from the literature is that-- in obese human subjects who conform to the conditions that I've described above-- leptin injections have proved to be almost worthless; they only start working after subjects have dieted for extended periods of time or in the already extremely lean.

That right there is very critical to understanding the 'ceiling in relation to the floor' when it comes to serum leptin concentrations and how they respond to changes in energy balance...

Unless we hear something earlier, there will be an Avant Labs chat on Tuesday, Feb. 16, at 9:00 PM eastern, and I'm sure Par will discuss the new stuff they have coming out, including Ghetto Leptigen