With both compounds being alpha-receptor agonists in the brain, would taking both supplements at the same time cause them to compete for the receptor and therefore decrease the effectiveness of both compounds?

Nobody got a clue?

I'd probably ask Patrick Arnold over at bb, since he was the first one to use ger. in AMP. He'd have probably done a lot of research on it, to know whether you could put it w/ yohimbine and be ok.

I don't know, personally, but I'm pretty sure he would. You could always call or email Ergopharm customer service, too. They [probably have contact info. on their web page. Let us know what you find out.

ya know, it might make them both work a little better. yohimbine can stimulate alpha and beta receptros, so if the alpha is being occupied by the geranamine, it's possible that the yohimbe would automatically fill in the beta....

or i could be full of crap.....

HEAT/AMP is a massively impressive combo - and the HEAT contains Alpha-Yohimbine.

Do you have data on Geranamine's binding affinities?

I'll look for it tonight. I saw it recently but don't remember where.

I know one thing for sure: geranamine can thwart your appetite. This is a great product for cutting.

yohimbe on the other hand, makes me feel, well, odd. It gives me an overall "something is wrong" type feeling. not a big fan except the huge erections it gives you.

This was all I could find from an article over at AM.




"1,3-Dimethylamylamine, “Geranamine”, mimics norepinephrine enough to bind to the norepinephrine reuptake transporter, but not enough to be taken up. Therefore, 1,3-Dimethylamylamine blocks the transporter, causing a buildup of norepinephrine in the synapse because it is not inactivated by reuptake. 1,3-Dimethylamylamine, like amphetamines, releases norepinephrine from nerve endings by converting the norepinephrine transporters into open channels (1). In fact, 1,3-Dimethylamylamine is more adrenergic than methamphetamine or amphetamine, but far less dopaminergic than the two (2). The more adrenergic, the more it mimics epinephrine. A study done in 1946 also shows this characteristic of 1,3-Dimethylamylamine. The study titled, Comparison Of Pressor Action Of Aliphatic Amines tested 46 different aliphatic amines on dogs, and out of the 46, 1,3-Dimethylamylamine was the most potent (3). Sounds a lot like AMP now doesn’t it? The bottle even says “adrenaline mimetic” right there on the front. Out of all the 46 different aliphatic amines, 1,3-Dimethylamylamine was most like epinephrine in intensity of action (3). It’s easy to see that PA was looking for a “revolutionary energy/fat loss formula” as it says on the bottle, and if you try to think like him for a moment, you too would want to come up with a compound that mimics adrenaline the best as an ephedra replacement. That compound is 1,3-Dimethylamylamine. Merck & Co., Inc. classifies 1,3-Dimethylamylamine as an a-adrenergic agonist (10). What is an a-adrenergic agonist? It is an adrenaline like drug that acts on the alpha-adrenergic receptor which causes vasoconstriction, uterine contractions, and mydriasis. Patrick Arnold said this about Geranamine, “I don't know details on what types of neurons this stuff effects in the brain. i really just know (and it has been documented) that it exhibits the classic peripheral effects of catecholamines in the body- tachycardia, pressor effects [see 1946 study above], mydriasis, etc. etc.” (5) On the same post, user “Zazou” thanks PA because he no longer has to take Provigil because AMP seems to work the same to him when he stays up late working. Provigil is also an alpha-adrenergic drug with more central effects compared to 1,3-Dimethylamylamine’s more peripheral effects (6).

Speak of the devil. I was just thinking about this thread. Anything yet Diesel?