We would love to see this sold at bulknutrition!

Kirk-The Luteinizer

Do you have any good data on it and/or its legality?

most research is on its anti cancer properties.

And then there is this.

J Agric Food Chem. 2003 Mar 26;51(7):1850-7. Related Articles, Links


Estrogenic activity in white and red wine extracts.

Klinge CM, Risinger KE, Watts MB, Beck V, Eder R, Jungbauer A.

Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA.

Red wine is enriched in resveratrol, trans-3,5,4'-trihydroxystilbene, a compound in grape skin that inhibits the development of pre-neoplastic lesions in mouse mammary tumor cells in culture and inhibits cancer cell proliferation in vitro. Grapes also contain other bioactive compounds including flavonoids, flavans, and anthocyanins. The estrogenic activities of extracts prepared from one white (Freie Weingartner Wachau, Gruner Veltliner, Austria) and two red wines (Woodbridge, Cabernet Sauvignon, California; and Lenz Moser Prestige, Blaufrankisch Barrique, Austria) were examined and compared with those induced by estradiol (E(2)) and trans-resveratrol. First, the estrogenic activity of the wine extracts was evaluated in a yeast estrogen screen (YES) assay, in which yeast express copper-inducible estrogen receptor alpha (ERalpha) and an estrogen-response-element (ERE)-driven beta-galactosidase reporter. In YES, the white wine extract showed no estrogenic activity. In contrast, both of the red wine extracts showed estrogenic activity equivalent to that of 0.2 nM E(2). Similarly, the white wine extract showed no transcriptional activity with either ERalpha and ERbeta in transiently transfected CHO-K1 cells. In contrast, both red wine extracts stimulated ERE-reporter activity in a concentration-dependent manner that was inhibited by 4-hydroxytamoxifen (4-OHT), indicating that the observed transcriptional activity was ER-mediated. The red wine extracts showed significantly higher ERbeta versus ERalpha agonist activity. Resveratrol showed no agonist activity in YES but activated ERalpha and ERbeta in CHO-K1 cells in a concentration-dependent manner that was inhibited by 4-OHT. This indicates that resveratrol requires mammalian cell components that are absent in yeast for estrogen agonist activity, whereas the estrogenic activity of wine extracts is directly through ERalpha and does not require mammalian cell factors such as coactivators. The estrogenic activity in red wine found by using YES indicates that estrogenic compounds other than resveratrol are present. Chemical analysis clearly showed that the trans-resveratrol content of the red wine extracts was 1 order of magnitude below the detection limit for YES assay.

PMID: 12643641 [PubMed - indexed for MEDLINE]

Im confused cause these studies confuse me

I was a business major, can you tell me what exactly that implied about wine...please tell me that one of the 2 is good for PCT!!!

Good to see others wanting bulk estrogen blockers. Does anybody know of studies on how resveratrol [trans-3,5,4'-trihydroxystilbene] compares with other nonprescription estrogen blockers such as DIM, indole-3-carbinol, or Diadzin?

Funny that u bumped up this thread, I was just researching resveratrol this morning.

diadzin is in formidal ..I found a site that sells formidal for 20 bux a bottle

I also would like to see how this compares to DIM,indole 3-carbinol, calcium d-glucarate, and others. What is the proper dosage and how much does it actually lower estrogen??