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Phosphatidyl Serine, Natural Cortisol Blocker? |  |
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 Would stacking something like Metacort and Phosphatidylserine be beneficial in cortisol suppression? Cost aside, anyway. Or would you just choose one or the other?
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 | QUOTE (Steven Tecson @ Jun 2 2004, 08:47 AM) | | Would stacking something like Metacort and Phosphatidylserine be beneficial in cortisol suppression? Cost aside, anyway. Or would you just choose one or the other? |
Cost aside... yes. However I do not think PS is worth the money unless you are using a low dose or have serious cortisol issues or Alzheimer's.
David Tolson
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Advanced Member

Group: Advanced Members
Posts: 428
Member No.: 41194
Joined: 30-August 04

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 PS usage may prevent Alzimer . then PS doesnt the bad side effect of bad cholesterol. for a long term usage. i will be nice to have a cheaper PS source since nowfoods PS is $30 for 12g !! sory it is $29.99 hehe . i personaly only swear by PS. i try to avoid 7-keto and DHEA as mutch as i can. I think PS is the way to go. i wil love to see a bulk PS by the killo. :-) This post has been edited by Saber41194 on Nov 6 2004, 11:16 AM
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 I use ps pretty often, I feel it helps my general daily stress, but I wouldnt rely on it to compensate for excessive sets, it helps but its not that powerful. If you added alot of time and sets in your workouts I think youd be dissapointed with it and end up overtrained and hit a plateu. And quite honestly a bit on the overpriced side, but I do like it when I can afford it. I have never heard of 7 keto DHEA being purported as a cortisol suppresant, its ussually marketed as a supplement for the purpose of supporting healthy thyroid function. The metacort also has 6 oxo in it, and may or may not reduce testosterone to estrogen conversion, subsequently resulting in more total testosterone, which could work in opposition to cortisol, but to what degree I cant say. Id suggest holding of on the ps unless your mood needs boosting, in which case you could add 5HTP, and Tyrosine to the PS as mood enhancing stack. Hope this helps you decide.
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 Usually for a cort lower response form PS you need upwards of a gram per day, which really isnt cost effective at all. I still think Lean Xtreme is the best for it followed by 7-oxo, if you used metacort you woudl be getting a dose of 6-oxo everything which you really dont need.
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Advanced Member

Group: Advanced Members
Posts: 428
Member No.: 41194
Joined: 30-August 04

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 | QUOTE (Monolith @ Nov 18 2004, 05:08 PM) | | QUOTE (Saber41194 @ Nov 6 2004, 11:14 AM) | PS usage may prevent Alzimer . then PS doesnt the bad side effect of bad cholesterol. for a long term usage. i will be nice to have a cheaper PS source since nowfoods PS is $30 for 12g !! sory it is $29.99 hehe .
i personaly only swear by PS. i try to avoid 7-keto and DHEA as mutch as i can. I think PS is the way to go.
i wil love to see a bulk PS by the killo. :-) |
lol. youve got $1500 to drop on a supplement that will barely do a damn thing in a person with normal endorcrinology?
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my last blood work(2month post-chronic-stress) showed 28 cortisol. Normal range is 4-25. When i was under chronic stress i didnt checked my cortisol. i gained 6kg of fat . now i am 61kg prety lean but still have the damn cortisol causing great headache after every meal. bulk PS by the killo will for sure be cheaper. Cost aside I NEED a better cortisol shutdown STACK!! PLZ helpMy curent stack is : Calcium citrate. Magnesium glycinate. Jujube Phenilbut Magnolia Bark L-theanine Valerian RootL-taurine Phosphatidyl SerineOmega-3-6-9ZMAnowfoods Multivits B5 I am consedering adding the folowing. I need your commentscholinelechitin ALpha-GPG 7-cort,Metacort L-dopa chocaminegreen TEA piracetam This post has been edited by Saber41194 on Nov 19 2004, 03:25 PM
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Advanced Member

Group: Advanced Members
Posts: 428
Member No.: 41194
Joined: 30-August 04

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 | QUOTE (Sldgehmr @ Nov 18 2004, 04:24 PM) | Usually for a cort lower response form PS you need upwards of a gram per day, which really isnt cost effective at all.
I still think Lean Xtreme is the best for it followed by 7-oxo, if you used metacort you woudl be getting a dose of 6-oxo everything which you really dont need. |
i would love to try lean Xtrem. But $40 is a bit too mutch for me. $40 for 15 days at the maximum dosage What kind of cortisol reduction can i expect from lean xtrem ? may be 20-30% in the course 15day ? | QUOTE (David Tolson @ 7-OXO Science) | 7-oxo-DHEA may inhibit the production of cortisol by 11betaHSD1 in in vivo situations, and this may be involved to some degree in the antiglucocorticoid action of 7-oxo-DHEA and related compounds. Sulcova et al. performed a study in men involving transdermal administration of 25 mg 7-oxo-DHEA for five days, and circulating cortisol levels decreased by 7.4%, but the effect was not statistically significant, although it was close [22]. Also, in the results reported by Davidson et al., cortisol levels decreased by 7.7% over eight weeks, but again this was not statistically significant [7]. Thus, the present research suggests that 7-oxo-DHEA functionally reduces cortisol levels, but further research should be conducted to confirm this.
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I will need to get my hands on 4 botle of Lean Xtrem at the cost of $160 to last 8 week @Maximum dosing. 8 week of 7-OXO to reduce my cort level from 28 to 26.But why 7-OH make 7-oxo, 7-oxo ethers and 7-oxo transdermals obsolete ? What are the researche behind thos claims ? i realy need another blood work to confirm that my cortisol has dropped after it's use @Sldgehmr why 6-oxo is bad thougth that testo increase may reduce the impact of cortisol on imune systeme and muscles This post has been edited by Saber41194 on Nov 20 2004, 02:41 PM
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 Ok Ill try and answer all of these. Lets say you have a 20% reduction in Cortisol that would be more then double the drop from 7-oxo. Does 7-oxo cost less then 50% of Lean Xtreme? My guess is that it will lower it more then 20%, I dont know for sure I havent had blood work done on it yet, but from my own exp. it has severly lowered my C levels so much that I had to use a smaller dose. My joints just got too sore. Also it shouldnt matter the cost if it really works (I dont think 7-oxo or PS works as well as this) and helps. I suffer from terrible migraines, I used Imitrex to treat them and when Imitrex first came out it cost me $900 for a 3 month supply. It was well worth it and that time. But these should have relevance for what you would be using this for: Neurosteroid 7-hydroxylation products in the brain. Shows that alpha-hydroxysteroids was a key event for the neuroprotection conferred by neurosteroids Neurosteroid metabolism. 7 alpha-Hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes. Shows 7 alpha-OH compounds may contribute to the control of neurosteroid activity in brain. Now the reason it makes other obsolete is because it is the perferred hormone for the human body, meaning that this is the form that works the best and it works great orally, which 7-oxo does not. Does this help at all?
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 I am not sure if using green tea will help you reduce cortisol levels in your blood. The reason is that green tea contains caffeine which stimulates your adrenal system which is responsible for secreting stress hormones such as cortisol. You may want to go a little more low tech and low cost. Insulin management is perhaps your most effective way to combat cortisol. Try eating nine meals a day containing carbohydrates, fats, and proteins in relatively sane portions (like 50%, 15%, 35% for a total of at least 200kcals per meal). Insulin is a cortisol antagonist. Yoga, meditation, and cognitive behavior therapy are also useful for stress. They are also somewhat inter-related. An integrated approach would stand a greater chance of being effective rather than just taking in supplements/drugs. Stress seems to be a long-term issue for most people and thus it makes sense when the approach to combat stress is sustainable over the course of your lifetime.
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