With regards to methylated PHs such as M1T and Methyl-Dien, is it better to run liver protection supplements (such as milk thistle, NAC, ALA, ALCAR) during the cycle, or just pre and post cycle? I've heard opinions both ways. Also would it be better, worse, or no difference to run them pre-during-and post cycle? Could running these supplements during the the cycle harm the bioavailability of the methylated PH?
Thanks for your honest opinions!
sp

IMO, NAC, ALA, and ALCAR should be run year round. Although, ALCAR is not an anti oxidant, but should be a main stay in most any supplementation regimen. As far as when to run Milk Thistle, during or after is fine, it probaly wont make too much of a difference either way.

I've looked around and have seen a lot of takes on liver protection concerning M1T and Methyl-Dien.

Would 600mg ED of R-ALA be adequate?

Of course I understand that adding supps like pro-liver would be of further benefit...

Regarding what types of liver protectants to take, yeah, you'll find a lot of differing opinions, most of which aren't really backed by any science at all but also aren't necessarily harmful.

You should never hear differing opinions of WHEN to take, though, unless like with pro who suggested year-round NAC and ALA (and ALCAR, but the first two mentioned mostly for the sake of the subject). The time should be a no brainer. Let's see here...you're (not you specifically sweet-physique; I know you're just asking a question so I'm not flaming you or anything) taking androgens. Ones that, while this is very very overexaggerated, can potentially harm your liver. As these androgens have very short active lives in the body, it makes sense to assume that this potentially-liver-harming process takes place at a relatively "current" rate; or in other words, it's not gonna happen 23 days in the future -- it's happening now.

Okay. So this potentially-liver-harming process is taking place while you're on the androgens. Your desire is to protect your liver. You want to protect your liver while it's potentially being harmed. It's potentially being harmed now. Thus, you want to take your liver protectants now. Or, in other words, you probably want to take them ON CYCLE. Continuing to take them off-cycle during PCT isn't a bad idea either.

The problem with these new "theories" on when to take stuff is that since M1T and methyldien came out, way too many 16, 17, 18 year olds are trying to get creative and cute with the way they're doing it because they want people to think they're smart or that since they're doing it differently, they must know something. That and it's all bro-science, gym lore, whatever you wanna call it.

Thanks pro and Kow. What you both said makes sense. If / when I do take the meth. PHs I will run the ancillary liver supps. during and PCT. I already take ALA all the time but not the NAC or ALCAR. I'll rethink this maybe.
BTW here my stats.
Age 34
Wt. 235
Ht 6'2"
B/f low teens 11-13%
Years lifting 14.
Past PH exp. 2 cycles 1test, 4ad for one and 1ad for another

Check out Mike's Pro-Liver (the 1fast400 brand). It's an NAC/milk thistle mix and is priced very competitively.

I used Mikes R-Ala while doing blood tests for MDien (10mgs) and using 600-1800mgs per day lowered liver enzyme values by about 25%.

so that is what i would use.