| QUOTE (Caleb Stone @ Mar 15 2005, 01:41 PM) |
| Here's my write-up on it from H.E.A.T. "Tyramine is a trace amine found in the human body and many foods such as wine and aged cheese. How it was generally overlooked as a supplement until now is utterly baffling to me. This is an amazing little compound. First, it will go a very long way toward replacing Ephedrine with its stimulation of NE release. In fact, it is used clinically for this very purpose. It does so by acting as a competitive inhibitor of NE uptake at its transporter. Nerve terminals take up tyramine instead of NE, leaving more NE free to work its magic. In addition, it aids the cause further by competing strongly with NE for metabolism by MAO-A. Tyramine’s real magic, IMO (remember, we go beyond ephedra here today), is in increasing the neurotransmitter dopamine. Not only is it directly converted to dopamine via CYP-2D6, but it also decreases its metabolism via MAO-A inhibition. In fact, the literature has found it to be superior at increasing dopamine than increasing NE. And, injections of tyramine cause an overall vasodilation in skeletal muscle consistent with increased dopamine, as opposed to vasoconstriction, which would be consistent with NE. Finally, some very new research has identified a trace amine receptor in rats, which is very strongly activiated by tyramine. Activation of this receptor results in an increase in the lipolytic adenyl cyclase. Beyond that, the data is too new and too scarce to come to any real conclusions. However, a number of drugs, which are strongly involved in dopaminergic transmissions and appetite suppression also strongly activate these, including amphetamine, MDMA, and dopamine metabolites. " |
Wow. it increases the half life of norepinephrine, AND increases dopamine levels? Im seeing some interesting possabilities and stacks. im going to do some serious research now that i know about it thanks guys, but with the potential it holds, how come its so little known as a supplement? and any ideas on dosages? thanks alot 