Tyramine Powder

ive only seen research on tyramine being a health hazard for some people. what are the benefits?

Here's my write-up on it from H.E.A.T.


"Tyramine is a trace amine found in the human body and many foods such as wine and aged cheese. How it was generally overlooked as a supplement until now is utterly baffling to me. This is an amazing little compound.

First, it will go a very long way toward replacing Ephedrine with its stimulation of NE release. In fact, it is used clinically for this very purpose. It does so by acting as a competitive inhibitor of NE uptake at its transporter. Nerve terminals take up tyramine instead of NE, leaving more NE free to work its magic. In addition, it aids the cause further by competing strongly with NE for metabolism by MAO-A.

Tyramine’s real magic, IMO (remember, we go beyond ephedra here today), is in increasing the neurotransmitter dopamine. Not only is it directly converted to dopamine via CYP-2D6, but it also decreases its metabolism via MAO-A inhibition. In fact, the literature has found it to be superior at increasing dopamine than increasing NE. And, injections of tyramine cause an overall vasodilation in skeletal muscle consistent with increased dopamine, as opposed to vasoconstriction, which would be consistent with NE.

Finally, some very new research has identified a trace amine receptor in rats, which is very strongly activiated by tyramine. Activation of this receptor results in an increase in the lipolytic adenyl cyclase. Beyond that, the data is too new and too scarce to come to any real conclusions. However, a number of drugs, which are strongly involved in dopaminergic transmissions and appetite suppression also strongly activate these, including amphetamine, MDMA, and dopamine metabolites. "

I think the reason it has not been popular at all as a supplement until HEAT is because of the MAOI/"cheese effect" association. Basically, in combination with an MAOI, it can cause a dangerous increase in blood pressure. But, even this is way overstated amongst laymen when compared to the literature.

The other flaw, which is related, is that MAO metabolizes a lot of it in the gut (and elsewhere), so the bioavailability is low and can be variable.

If not for MAO, it would be very reminiscent of cocaine.

As far as dosing, I don't want to go to accurate because it is in our product, so start low (like 50mg) and it is very unlikely that you would want to exceed 300-400mg

thx alot caleb ill pick some up and try it out.

Not many uses MAOI anyway, I know I dont.

How about transdermal tyramine?

I've intended to experiment with a systemic transdermal, but I have not gotten around to it. It is in Lipo Ultra, but that is locally acting.

In a systemic transdermal, it would bypass the gut and liver, which have high levels of MAO, so it could be pretty potent.

Caleb, thanks for your info on Triamine! I tried it, and it worked well, but I have two concerns.

1. It stimulated my digestive system to the point were it was digesting my stomach. (The amino acids I'm taking probably didn't help, but triamine seemed to be the main culprit.)

2. Other chemicals that raise dopamine levels (e.g., amphetamines, ritalin/cocaine) tend to be safe only in low-dose time-release formulations.

I'd be grateful if someone could point me to info on how to mix up a low-dose time-release systemic topical.

Interested users might find this info useful:
http://circ.ahajournals.org/cgi/content/fu...onaha;109/3/e17
....although arguable they're talking about an IV-based dose...

Quote:
"""Jacob et al1 recently reported that systemic administration of tyramine, which is widely used as a pharmacological tool to assess sympathetic nervous system function, resulted in unexpected and seemingly paradoxical forearm vasodilation.1 Tyramine infusion is well known to increase entry of the sympathetic neurotransmitter, norepinephrine, into the extracellular fluid. By this indirect sympathomimetic effect, one would expect increased peripheral resistance to blood flow in tissues possessing sympathetic noradrenergic innervation. Instead, systemic tyramine infusion produced a clear decrease in forearm vascular resistance despite concurrently increased forearm norepinephrine spillover.

In the same study, plasma levels of dopamine increased remarkably, by {approx}50-fold, during tyramine infusion. The authors speculated that circulating dopamine, released or produced from tyramine, might mediate the paradoxical vasodilation. Dopamine might be released with norepinephrine from sympathetic nerves, or tyramine might be converted enzymatically to dopamine in the liver. The authors concluded with the hypothesis that tyramine-induced release of other bioactive amines (eg, dopamine) plays a role in this paradoxical effect."""

See also:
http://www.ncbi.nlm.nih.gov/pubmed/12707242?dopt=Abstract
(as referenced in the article above)