My suppliment usage and a bad liver panel

1Fast400 Forums > Supplements



Posted by: Ronn Apr 3 2004, 12:56 AM
My doctor's office called me today (24 hours after my blood test) and told me my liver panel came back "abnormal." I was speaking with an office clerk, so my information is sketchy, but my doctor wanted to know if I was on "water pills" or if I'd been sick lately?

From what I gleaned, my panels would indicate that my liver is symptomatic of dehydration. My doctor wanted me to get another blood test right away and then she'd see if things were better, otherwise she wanted to see me immediately (my appointment on the 14th of this month was not soon enough). When my blood was drawn for this test, I had been fasting for 12 hours--but the doctor knew that.

So I'm wondering if something/somethings I'm taking may be affecting my liver.

I'm just ending a 4 week cycle of 16 sprays a day of S+1, but seeing as that is a transdermal I shouldn't think there's an issue by the way, my gains on S+1 didn't kick in until week four!) I finished a 4-week cycle of 1AD (600mgs daily) and 1,4 doil (600) about 4 weeks prior to that--yet again, nothing I used was mentholated.

Over two servings, I take a total daily dose of:
1-2 grms of ALC
200 to 400 ALA
2 grms Choline
6 grms Vit C
1.6 grms Piracetam
5-8 grms DMEA
100 mgs Q10
6 grms fish oil
600 IU vit E
200mc Chromium Picolinate
20,000iu beta carotene
The for the following I'm guessing, as I don't have the bottles in front of me;
200% calcium/magnesium
10 Sal Pemento berry caplets
Garlic Tablet (=1 large clove)
A multi-vitamin

5-8 grms Creatine on training days (4 days per week)

Macronutrients are roughly a 40/40/20 P/C/F spread

In addition, over the last week I've been taking 500-1000mgs of Aleve per day for joint pain.

I may indeed simply be dehydrated. Though if I am it's surely news to me, and why an immediate appointment? I plan on drinking lots of water and getting blood drawn again on Thursday.

Any idea's--Am I missing something in the above that is obvious to a more seasoned eye? What should I ask my doctor after the next test, and could you all point me to some articles or threads that could be of help concerning the effects of various supplements (like those outlined above) on liver function?

Thanks,

Ronn





Posted by: CYPHON Apr 3 2004, 01:05 AM
A combination of creatine and not enough water may be your problem.........Aleve certainly would agravate the liver some. Your diet looks great. Drink a gallon of water a day or more.

Posted by: Ronn Apr 3 2004, 10:03 AM
Ops, I forgot three potentially important items.

Prescription Drugs:

Norvac 10mgs
Benicor 20 mgs (both for blood pressure)
Clarinex 10mgs (allergies)

And thanks for the reply. I had wondered if my water intake had just started creeping lower and lower and I hadn?t noticed it due to my increasing workload at the college. I?m going to try drinking by the clock for a while; 16oz. every two hours.

Ronn

Posted by: MaynardMeek Apr 3 2004, 11:55 AM
No everything looks alright. You have to drink more water as said above.. eiter a gal. a day or some find that a gal. per 100 pounds.



Posted by: Strateg0s Apr 3 2004, 03:30 PM
Your liver values could have been skewed if you exercised recently (w/in 2 days)before the blood draw, or if you had eaten (<12hrs). Did your doctor know which medication you were on? - and did you do a 'control' blood test, before starting you androgen use, so you would have a baseline to make comparisons from?

Posted by: shpongled Apr 3 2004, 04:57 PM
A few comments...

1. 5-8 grams DMEA, is that DMAE? If so, that's toxic levels there...

2. 1-test will still be metabolized by the liver (even when administered transdermally), and may in theory put some stress on it. A lot of it should be metabolized in other tissues, which will lighten the workload, but stress on the liver is still possible with a transdermal.

3. The S1+ could indirectly be causing this effect - steroids cause many physiological changes. These include changes in electrolyte balance, which changes the hydration state of the body. However, I would think that you would be seeing hyperhydration, not dehydration.

I don't see how any of the other supplements could cause a problem, most are good for the liver.

As far as dehydration goes, sometimes drinking too much water will only make the problem worse. It depends on the source of the dehydration. Way too many people think drinking more water is always the solution, when dehydration can be indicative of a larger problem. This actually gets people killed sometimes. I think half a gallon of water a day is fine, definitely not more than a gallon. If you are drinking a lot of water, you need to make sure to get adequate electrolytes as well, as there will be obligatory electrolyte excretion. My advice:

-Ensure adequate water intake but don't overdo it.

-Get your liver values tested again a few weeks after your cycle is over. If there is still a problem, there is more reason for concern, and you should work at trying to determine the cause.

Posted by: Ronn Apr 3 2004, 09:38 PM
QUOTE
1. 5-8 grams DMEA, is that DMAE? If so, that's toxic levels there...


OK--that goes right to the top of my "things I REALLY need to know" list. Thanks! Since you posted your reply, I've read your article regarding DMAE and I've decided to completely remove it from my supplement mix. I had originally included it in an attempt to work on a Ritalin-free approach to dealing with my ADD.

Again, many thanks for the heads up!!!


Strateg0s-
My doctor has blood work done once a year as part of my general health care. In the past my panels have always come back fine (using the prescription meds and working out). As this is only my second PH cycle, I've had no "baseline" test taken immediately prior to beginning my first cycle and thus they were my major concern. If the test on Thursday doesn’t look good, I'll show her my supp. list, including 6OXO and brace myself to the disapproving looks wink.gif

Ronn



Posted by: shpongled Apr 6 2004, 09:23 AM
That could've conceivably been the problem right there - given that choline is an important liver nutrient, and DMAE displaces it. I really don't think it is worth taking as a supplement, since the effects are so unpredictable depending on conditions, and there are high indications of toxicity.

Regarding ADD, a few studies (in children) have shown L-carnitine to be beneficial, especially in terms of increasing concentration ability. Not enough to make it well established, but it's a good all-around supplement.

Posted by: everett26393 May 11 2004, 03:01 AM
Hi.Why dont you check in to the liver toxicity of b carotene?
Everett

Posted by: tabreaux Jun 28 2004, 01:13 PM
QUOTE (Ronn @ Apr 3 2004, 12:56 AM)
20,000iu beta carotene


Back off on that Beta Carotene.

See below:


From: http://nutritionfocus.com/nutrition_supplementation/vitamins/beta-carotene.html#7

BETA CAROTENE - SIGNS OF TOXICITY
50,000 IU's (provitamin A) daily may be toxic, 18,500 IU's (provitamin A) daily for 1-3 months toxic for infants, 25,000 IU's (provitamin A) can produce liver damage, large doses lead to anemia and gout, anemia, blurred vision, bone pain, diarrhea, fatigue, gout, hair loss, headaches, irregular periods, liver enlargement, nausea, vomiting. Prolonged excessive intake results in abnormalities in skin, eyes, and mucous membranes, blurred vision, bone fragility, deep bone pain, enlargement of liver and spleen, reduced thyroid activity, skin rashes, thickening of long bones. If toxicity is detected, the symptoms will disappear in a few days after the vitamin is withdrawn. (An International Unit (IU) of Vitamin A is equivalent to 0.6 mcg of beta-Carotene)

Additionally, ingestion alcohol exacerbates any toxic effects.


You should consider backing off all that DMAE as well.


Posted by: Clay25188 Jun 28 2004, 02:30 PM
On top of all of the stuff listed, your allergy medication may be dehydrating you as well.

Posted by: brion1234 Jun 29 2004, 01:27 AM
Hi,

I have studied the stuff extensively and I agree exactly with what people already mentioned. The beta carotene and the DMAE. Beta C can be toxic, it has a synergistic affect with other supplements and this can cause it to metabolize much higher amounts then even what it seems your taking. DMAE is a very dangerous hormone and I would suggest you research it fully... HOWEVER, more times then not its probably just the fact you were fasting and still taking all your supp's without enough water when you fasted. I would be concerned still however. drink much more water, and be sure to reduce those two.

Posted by: Got Trip? Jan 2 2005, 04:07 PM
QUOTE
DMAE is a very dangerous hormone...


Err...i was under the impression that it was not a hormone...

Posted by: matt29524 Jan 3 2005, 05:50 PM
QUOTE (Ronn @ Apr 3 2004, 12:56 AM)
In addition, over the last week I've been taking 500-1000mgs of Aleve per day for joint pain.


Right there may be your problem. Did you take it the day before the test?? I was taking presciption anti-inflammatories (=about 1000mg of ibuprofen/day) and took them about 4 pm the day before my bloodwork. Tested the next morning (fasting) & my liver values came back 4.5-5 times the normal levels. I stopped taking it & took milk thistle and retested a month later & was right back in line.

Doc said any anti-inflamatories can bump your liver levels way up while on them. That's why it says dont take for more than 7-10 days on the bottle.

Just my experience for what it's worth.

Posted by: Wicked Girl Feb 28 2005, 09:56 PM
Definitely the Aleve could be a problem. Also, you are mixing an incredible amount of presciptive drugs and supplements. Not a good idea.

Posted by: Just me Mar 7 2005, 09:27 AM
Saw Palmetto?? This stuff works by blocking the effects of testosterone on the prostate, and the rest of the body, and allowing the prostate to shrink some if it is swollen. Bodybuilders should not take Saw Palmetto. It blocks testosterone effects over the entire body. You are essentially castratiing yourself. Testosterone effects on the muscles are also blocked with this supplement.

Posted by: gordongecko Mar 7 2005, 02:04 PM
QUOTE (Just me @ Mar 7 2005, 09:27 AM)
Saw Palmetto??  This stuff works by blocking the effects of testosterone on the prostate, and the rest of the body, and allowing the prostate to shrink some if it is swollen.  Bodybuilders should not take Saw Palmetto.  It blocks testosterone effects over the entire body.  You are essentially castratiing yourself.  Testosterone effects on the muscles are also blocked with this supplement.

"What is interesting about the 5AR inhibition caused by saw palmetto is that it is prostate-specific. Not only does saw palmetto inhibit both types of 5AR in the prostate but not in other tested tissues (epididymis, testes, kidney, skin, and breast) in vitro [20], the active ingredients of saw palmetto concentrate in the prostate as opposed to other tissues after oral administration to rats [21]. This is in line with human studies indicating that saw palmetto extract preferentially reduces prostatic DHT and does not alter plasma DHT or sex hormone levels [9, 22-23]. This explains the lack of side effects in clinical trials. It also means that saw palmetto is unlikely to prevent hair loss."


--Ripped from article on site.

Posted by: sdf42450 Mar 7 2005, 02:10 PM
i'd say its the aleve... i'd lay off that if at all possible. you'll have a hard time putting on any muscle mass while taking that stuff (and esecially at the doses you are taking)

Posted by: BFiddy Mar 8 2005, 09:03 AM
I agree with everyone that told you to get off the aleve. There are various reasons to stay away from all types of pain-killers/anti-inflams.

However, it probably wasn't causing the problem. Your problem was dehydration, not raised liver enzyme values. Your doc was asking if you were taking water pills (diuretics)? You should've asked yourself if you were taking anything that acts as a diuretic. Because you are, AND at a very high dose. Vitamin C is a natural diuretic...and your intake was 6g/day. Definitely a contributing factor, if not the sole cause.