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 Check out David's article on milk thistle at the bottom here. It explains the utility pretty well. If you mean taking milk thistle PCT as opposed to taking it while on, there is no reason. Milk thistle should be taken DURING periods of extra stress on the liver. Methylated androgen cycles are a good example of times that the liver will be under extra stress. Whoever has perpetuated the myth that milk thistle while on is not necessary, should be only taken post-cycle, or will hurt gains on cycle is a dipshit.
"I don't like people who take drugs...Customs men, for example." - Mitch Miller
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 The way I figure it, you only have 1 liver, so keep it healthy year long regardless of whether or not you are on a cycle. I know I take milk thistle and R-ala year round and I recommend that anyone who drinks or does any type of activity that may in any way shape or form damage your liver to keep it protected, it is just practical. Fpot66
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 If you're more concerned with efficacy over safety, then I'm not sure what to suggest to you. Also, I know of no research showing that taking milk thistle decreases oral androgen efficacy. That doesn't mean there isn't any, though. Lastly, I highly, highly doubt that you will see any appreciable measure of decreased potency of methylated steroids with concurrent milk thistle use.
"I don't like people who take drugs...Customs men, for example." - Mitch Miller
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 | QUOTE (James39028 @ Aug 17 2004, 12:11 PM) | Problems with kidneys have not been an issue to my knowledge. I feel that this is a bad idea. When you use compounds that increase gluthione levels in the liver, it will increase the breakdown of oral drugs, making them less effective. Although increasing liver enzymes is good for your liver, it is bad for any drugs you want to take and allow them to pass through your liver unabated. A better idea would be to use liver protectant supplements before and after a cycle to help your liver rebuild its enzymes after they have been damaged by methylated compounds. So I was thinking before for 2 weeks and after for 2 weeks. What are your thoughts? |
This is untrue Methyls bypass even a healthy liver Glutathione does not metabolize drugs, it prevents oxidative stress (although this can reduce drug metabolization enzymes if it gets bad enough - you do not want it to get to this point though). Think about it this way. If you have a healthy liver, you can drink alcohol, and still get plenty drunk. Just as oral androgens will work fine if you have a healthy liver. Purposefully destroying your liver to increase the bioavailability of drugs is not a smart thing to do.
David Tolson
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 I would use it after a cycle that includes orals. Otherwise you are wasting part of the orals you are taking. By keeping the liver "healthy", it is able to process and remove the more of the orals from your system. You don't want a "souped up" liver right when you start, it'll lower the effectiveness of the oral gear you take for the first few weeks. Id just go in normal. The liver "damage" caused by methylated gear is greatly exaggerated. Id use the Milk Thistle post cycle to assist the liver in regenerating.
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 To sort-of echo a point Rwyan made: When dealing with things that are hepatoxic such as methylated androgens, accutane, acetaminophen, etc., when exactly do you think liver problems such as jaundice and others associated with liver failure occur? Do you think they occur during the cycle as a result of an overdose (an overdose with respect to how much your liver can handle, not necessarily an overdose in the sense of ODing on crack), or do you think they just pop up out of nowhere somewhere down the line? While both do occur, which do you think gives medical professionals now and in the past reason to monitor your liver values WHILE ON CYCLE? Why do you think people are cautioned to monitor liver values or take medications to keep liver values in check WHILE TAKING THEIR MEDICATIONS?
That's a pretty rhetorical question so I'll let you answer it. However, if getting an extra 10-20% effectiveness that 1) you aren't going to see real-world, and 2) won't really even occur, as David stated that methyls pass even a healthy liver is more important to you than prevention of a possible fatal condition, I don't know what to tell you. I know liver toxicity is severely overstated, but it's not for those who have existing liver problems but aren't aware of them.
"I don't like people who take drugs...Customs men, for example." - Mitch Miller
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