I've read the user reviews for Sulbutiamine and, as with all the nootropics here, the reviews range from 'spectacularly cocaine-like' to ' tastes shitty, did nothing.' Before trying it out myself, I figured I'd ask for people's experiences with it here (as well as with caffeine free SPIKE, which contains only Sulbutiamine).

Is this another so subtle, you can't tell product, or is this something that one can positively say is not placebo?

Anybody?

I've never noticed anything from it. Might be good for alcoholics.

[Effects of the association of sulbutiamine with an acetylcholinesterase inhibitor in early stage and moderate Alzheimer disease][Article in French]


Ollat H, Laurent B, Bakchine S, Michel BF, Touchon J, Dubois B.
Association pour la Neuro Psycho Pharmacologie, 25 rue de la Plaine, 75020 Paris.

The efficacy of the inhibitors of acetylcholinesterase in Alzheimer's Disease (AD) is moderated and some patients do not respond to these treatments. Sulbutiamine potentializes cholinergic and glutamatergic transmissions, mainly in hippocampus and prefrontal cortex. This multicentric, randomized and double-blind trial evaluates the effects of the association of sulbutiamine to an anticholinesterasic drug in cognitive functions in patients with AD at an early stage (episodic memory, working memory, executive functions, attention). Patients had first donepezil (D) or sulbutiamine (S) during three months. During this period, only attention improved in both groups. During the three following months, a placebo (P) in patients D and donepezil in patients S were added. Compared to entry results, episodic memory decreased in group D + P but improved in group S + D. At the same time the improvement of attention persisted in both groups. Daylife activities only improved in group S + D. In conclusion sulbutiamine can be an adjuvant to treatment in early stage and moderate AD by anticholinesterasic drugs.

PMID: 17675917 [PubMed - indexed for MEDLINE

So from this study:

If one were wanting to aid in mental function with supplementation, a good combo would be something like Huperzine + Sulbutiamine + Aniracetam. The reasoning for the addition of aniracetam would be because Huperzine is a dual Achesterase inhibitor as well as a NMDA receptor antagonist (similar to memantine). The addition of Aniracetam would prevent some of the negative aspects of NMDA antagonism, while aiding synergistically with huperzine's inherant cholinergic effects (and sulbutiamines synergy as explained in the abstract above).

Remember that the theraputic effects from sulbutiamine come from something like 1 gram per day, so it may be slightly cost prohibitive.

Thanks for the replies guys. This substance doesn't sound to promising.