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 ya know, it might make them both work a little better. yohimbine can stimulate alpha and beta receptros, so if the alpha is being occupied by the geranamine, it's possible that the yohimbe would automatically fill in the beta.... or i could be full of crap.....
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HEAT/ AMP is a massively impressive combo - and the HEAT contains Alpha-Yohimbine. Do you have data on Geranamine's binding affinities? RecompPerformanceNutrition
"Blood, Sweat, and Tears does not mean crying while you struggle to put your tampon in." ~dsade
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Delivering you the truth in 30 minutes or it's free
Group: Advanced Members
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This was all I could find from an article over at AM. "1,3-Dimethylamylamine, “Geranamine”, mimics norepinephrine enough to bind to the norepinephrine reuptake transporter, but not enough to be taken up. Therefore, 1,3-Dimethylamylamine blocks the transporter, causing a buildup of norepinephrine in the synapse because it is not inactivated by reuptake. 1,3-Dimethylamylamine, like amphetamines, releases norepinephrine from nerve endings by converting the norepinephrine transporters into open channels (1). In fact, 1,3-Dimethylamylamine is more adrenergic than methamphetamine or amphetamine, but far less dopaminergic than the two (2). The more adrenergic, the more it mimics epinephrine. A study done in 1946 also shows this characteristic of 1,3-Dimethylamylamine. The study titled, Comparison Of Pressor Action Of Aliphatic Amines tested 46 different aliphatic amines on dogs, and out of the 46, 1,3-Dimethylamylamine was the most potent (3). Sounds a lot like AMP now doesn’t it? The bottle even says “adrenaline mimetic” right there on the front. Out of all the 46 different aliphatic amines, 1,3-Dimethylamylamine was most like epinephrine in intensity of action (3). It’s easy to see that PA was looking for a “revolutionary energy/fat loss formula” as it says on the bottle, and if you try to think like him for a moment, you too would want to come up with a compound that mimics adrenaline the best as an ephedra replacement. That compound is 1,3-Dimethylamylamine. Merck & Co., Inc. classifies 1,3-Dimethylamylamine as an a-adrenergic agonist (10). What is an a-adrenergic agonist? It is an adrenaline like drug that acts on the alpha-adrenergic receptor which causes vasoconstriction, uterine contractions, and mydriasis. Patrick Arnold said this about Geranamine, “I don't know details on what types of neurons this stuff effects in the brain. i really just know (and it has been documented) that it exhibits the classic peripheral effects of catecholamines in the body- tachycardia, pressor effects [see 1946 study above], mydriasis, etc. etc.” (5) On the same post, user “Zazou” thanks PA because he no longer has to take Provigil because AMP seems to work the same to him when he stays up late working. Provigil is also an alpha-adrenergic drug with more central effects compared to 1,3-Dimethylamylamine’s more peripheral effects (6). The great majority of mankind are satisfied with appearances as though they were realities, and are more often influenced by the things that seem than by those that are. --- Niccolo Machiavelli
I like my women the same way I like my coffee: ground up and put in the freezer.
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Can i buy some Pot from you?
Group: Advanced Members
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| QUOTE (joseph23573 @ Mar 25 2008, 02:47 PM) | | yohimbe on the other hand, makes me feel, well, odd. It gives me an overall "something is wrong" type feeling. not a big fan except the huge erections it gives you. |
I have to agree with that statement. When i first started taking Yohimbe i would get this weird, disconnected feeling. It would teter on the verge of intoxication. I still to this day get very irritated on yohimbe...fight or flight syndrome kicks in BIG time. African warriors would eat/chew/smoke yohimbe bark prior to tribal battles and Lion hunting to create a feeling of invinsibilty and mania. That pretty much says it all. Anyway, Ive used both geranamine and Yohimbe together. i couldnt tell you from a scientific standpoint whether they cancel each other out or if they're synergistic but...I believe it gave me a mild form of Mania. Also, The crash was rediculous. However, it should be noted that i took 200mg of Geranamine which to my understanding now is 4 X the recommended dosage. I may of even had Ephedrine in my system at the time. I have the CNS stimulant tolerance of Tyrone Biggums and im sure all my receptors are shot....so perhaps my experiences are atypical and not the norm.
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| QUOTE (AdamGrossman @ Mar 25 2008, 07:39 PM) | This was all I could find from an article over at AM.
"1,3-Dimethylamylamine, “Geranamine”, mimics norepinephrine enough to bind to the norepinephrine reuptake transporter, but not enough to be taken up. Therefore, 1,3-Dimethylamylamine blocks the transporter, causing a buildup of norepinephrine in the synapse because it is not inactivated by reuptake. 1,3-Dimethylamylamine, like amphetamines, releases norepinephrine from nerve endings by converting the norepinephrine transporters into open channels (1). In fact, 1,3-Dimethylamylamine is more adrenergic than methamphetamine or amphetamine, but far less dopaminergic than the two (2). The more adrenergic, the more it mimics epinephrine. A study done in 1946 also shows this characteristic of 1,3-Dimethylamylamine. The study titled, Comparison Of Pressor Action Of Aliphatic Amines tested 46 different aliphatic amines on dogs, and out of the 46, 1,3-Dimethylamylamine was the most potent (3). Sounds a lot like AMP now doesn’t it? The bottle even says “adrenaline mimetic” right there on the front. Out of all the 46 different aliphatic amines, 1,3-Dimethylamylamine was most like epinephrine in intensity of action (3). It’s easy to see that PA was looking for a “revolutionary energy/fat loss formula” as it says on the bottle, and if you try to think like him for a moment, you too would want to come up with a compound that mimics adrenaline the best as an ephedra replacement. That compound is 1,3-Dimethylamylamine. Merck & Co., Inc. classifies 1,3-Dimethylamylamine as an a-adrenergic agonist (10). What is an a-adrenergic agonist? It is an adrenaline like drug that acts on the alpha-adrenergic receptor which causes vasoconstriction, uterine contractions, and mydriasis. Patrick Arnold said this about Geranamine, “I don't know details on what types of neurons this stuff effects in the brain. i really just know (and it has been documented) that it exhibits the classic peripheral effects of catecholamines in the body- tachycardia, pressor effects [see 1946 study above], mydriasis, etc. etc.” (5) On the same post, user “Zazou” thanks PA because he no longer has to take Provigil because AMP seems to work the same to him when he stays up late working. Provigil is also an alpha-adrenergic drug with more central effects compared to 1,3-Dimethylamylamine’s more peripheral effects (6). |
whoever wrote that is very confused.
which is the problem when someone with no basis in neuroscience tries to 'put together all the peices,' so to speak.
i'll write about this later (workout time).
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Newbie
Group: Members
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| QUOTE (TheDiesel @ Mar 28 2008, 01:31 PM) | | QUOTE (AdamGrossman @ Mar 25 2008, 07:39 PM) | This was all I could find from an article over at AM.
"1,3-Dimethylamylamine, “Geranamine”, mimics norepinephrine enough to bind to the norepinephrine reuptake transporter, but not enough to be taken up. Therefore, 1,3-Dimethylamylamine blocks the transporter, causing a buildup of norepinephrine in the synapse because it is not inactivated by reuptake. 1,3-Dimethylamylamine, like amphetamines, releases norepinephrine from nerve endings by converting the norepinephrine transporters into open channels (1). In fact, 1,3-Dimethylamylamine is more adrenergic than methamphetamine or amphetamine, but far less dopaminergic than the two (2). The more adrenergic, the more it mimics epinephrine. A study done in 1946 also shows this characteristic of 1,3-Dimethylamylamine. The study titled, Comparison Of Pressor Action Of Aliphatic Amines tested 46 different aliphatic amines on dogs, and out of the 46, 1,3-Dimethylamylamine was the most potent (3). Sounds a lot like AMP now doesn’t it? The bottle even says “adrenaline mimetic” right there on the front. Out of all the 46 different aliphatic amines, 1,3-Dimethylamylamine was most like epinephrine in intensity of action (3). It’s easy to see that PA was looking for a “revolutionary energy/fat loss formula” as it says on the bottle, and if you try to think like him for a moment, you too would want to come up with a compound that mimics adrenaline the best as an ephedra replacement. That compound is 1,3-Dimethylamylamine. Merck & Co., Inc. classifies 1,3-Dimethylamylamine as an a-adrenergic agonist (10). What is an a-adrenergic agonist? It is an adrenaline like drug that acts on the alpha-adrenergic receptor which causes vasoconstriction, uterine contractions, and mydriasis. Patrick Arnold said this about Geranamine, “I don't know details on what types of neurons this stuff effects in the brain. i really just know (and it has been documented) that it exhibits the classic peripheral effects of catecholamines in the body- tachycardia, pressor effects [see 1946 study above], mydriasis, etc. etc.” (5) On the same post, user “Zazou” thanks PA because he no longer has to take Provigil because AMP seems to work the same to him when he stays up late working. Provigil is also an alpha-adrenergic drug with more central effects compared to 1,3-Dimethylamylamine’s more peripheral effects (6). |
whoever wrote that is very confused.
which is the problem when someone with no basis in neuroscience tries to 'put together all the peices,' so to speak.
i'll write about this later (workout time).
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Can you explain it the right way already TheDiesel? Your workout's probably done now. I'm very interested in the pharmacodynamics of 1,3-Dimethylamylamine. The metabolic pathways of pain and malaise evolved only because they served the inclusive fitness of our genes in the ancestral environment.
-David Pearce
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Geranamine + Yohimbine, alpha receptor competition?
