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> SERM / AI, when to use which?
Posted: May 21 2004, 09:06 AM
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Whats the difference between a SERM and an Aromatase Inhibitor and what does SERM stand for?? From what I understand, an AI prevents extra test from converting to estrogen by blocking receptors and a "SERM" soemhow reduces natural estrogen levels?? Also which ancillaries are AI's and which are SERMs? Thanks...
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Posted: May 21 2004, 09:54 AM
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SERM stands for Selective Estrogen Receptor Modulator. What these do are "block" estrogen at the receptor, or keep it from binding. You can think of these as very weak estrogens -- they bind to the ER (estrogen receptor), but because they are so weak, they exert little estrogenic effects on the body (they actually possess limited properties of estrogens, which is one reason for clomid's "mentally feminizing" effects). Because they bind to the site, they block other estrogens from binding and exerting their (more estrogenic) effects on the body. This is all pretty simplified but maybe you get the picture. Nolvadex and clomid are two of the more popular ones.

Aromatase inhibitors block the aromatase enzyme which is responsible for the conversion from testosterone to estradiol. This pretty much just lowers the amount of estradiol in the body but doesn't do anything with respect to how it binds. Common ones are arimidex, letrozole, and femara; pretty sure 6-OXO is one as well.

You pretty much had it right as far as what they do. This was just a little extra, probably unnecessary information for you smile.gif

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Posted: May 21 2004, 12:15 PM
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Thanks Kow, that's exactly the info I was looking for.
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Posted: May 22 2004, 11:31 AM
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So does a SERM like Nolva just serve to reduce estrogen levels or does it somehow translate into stimulating natural test production?? Thanks again..
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Posted: May 22 2004, 02:03 PM
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Nolva does both.So you could use as anti-estrogen or for pct.

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