Mr Stone,
I guess you've seen the nutrition science and lipid journal articles that show increased stability for sesamolin and sesolin under heating conditions when in the presence of antioxidants such as mixed tricotrienols and carotene. So the
Beyond the cooking oil format, why not consider a cold-pressed oil for use in salad dressings and for mixing with vegetables? Cold pressed oils are used at temps at or below boiling water, and are used in the same dishes one would use olive oil (as a dipping oil, for instance).'
Some Interesting Medical Benefit from use of this Product Forumation:
Of interest to product users, sesamin lignans have been studied for their anti-bacterial properties, which, I suppose, might be useful in reducing chances of food poisoning from improperly prepared foods when coated with this product (cold pressed oil; bacteriacidal properties may be less effective on prolonged heating.
A second and evident benefit from use of this product formulation may be action as a peridontal disease preventive and control agent, due to two-fold action of sesamolin as an inflammation reduction and antimicrobial agent.
Further, the action of sesamolins has yet to be investigated for dietary control approach (prevention of gastric colonization) and in-situ treatment of Heliobacter pylori, a microbial pathogen known to be associated with chronic ulcers and malignant hyperplastic differentiation of epigastic tissue.
Beyond fat metabolism and antibacterial properties, sesamin has been investigated for potential as a antihyperplastic (cancer), antispasmodic, and anti-inflammatory agents.
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The following section is thoroughly boring, technical reading, and of no useful advantage to the typical BN reader, and is provided as a useful reference to Mr Stone only.
I found interesting allegations for both anticancer and antiinflammatory actions of tethered bis(polyhydroxyphenyl) compounds (dicatechols), such as sesame and
curcumin (tumeric) lignans, which are common to a larger family of related plant compounds in a patent citation I came across recently:
From a 2004 Patent application (online search):
Functional Aspects of Bis(polyhydroxyphenyl) Compounds
Specific members of the bis(polyhydroxyphenyl) class of compounds have been documented as having anticarcinogenic activity evidenced by their ability to slow cell proliferation (Birt et al., 2001; Miquel et al., 2002; Thakkar et al., 1993; Wolter et al., 2002; Wieder et al., 2001; Blum et al., 2000) and a smaller number reportedly have weak anti-inflammatory effects (Blum et al., 2000; Gazit et al., 1989; Park et al., 2000; Chi et al., 2001; Cho et al., 2000; Kageura et al., 2001). For the most part, previous attention has focused on the linked members (especially flavonoids) rather than the tethered members and these studies have largely focused on anti-carcinogenic effects (Birt et al., 2001). In most instances the mechanism of bioactivity is not known. Specific bis(polyhydroxyphenyls), such as specific tyrphostins, resveratrol and piceatannol are thought to inhibit growth factor receptor tyrosine kinases (GF-RTKs) associated with uncontrolled cellular proliferation (Thakkar et al., 1993; Wolter et al., 2002; Wieder et al., 2001; Blum et al., 2000; Gazit et al., 1989).
Examples of bis(polyhydroxyphenyls) include flavones, flavanones, isoflavones and chalcones; specific tyrphostins containing two phenolic ring systems; hydroxylated stilbene derivatives such as resveratrol and piceatannol; and miscellaneous natural products including nordihydroguaiaretic acid (NDGA). When the two polyhydroxyphenyl groups are linked by a flexible carbonaceous chain (typically an alkyl chain of two or more atomic centers, containing or not containing other structural motifs such as C=C bonds, amide, sulfide, ester or ether linkages, or ketone moieties, the whole of which connects each ring exactly once), the structure can be accurately described as a tethered bis(polyhydroxyphenyl) or dicatechol. Thus, piceatannol, resveratrol and NDGA are tethered bis(polyhydroxyphenyls) and
curcumin is an O-alkyl derivative of the class. Contrastingly, flavonoids and the like, which are linked by constraining ring systems, are not tethered.
Much less work has focused on bis(polyhydroxyphenyl) effects on inflammatory diseases and virtually no work has focused on microglial biology per se. When bis(polyhydroxyphenyl) compounds have been studied in models of peripheral inflammation, attention has focused on the linked (but not tethered) subclass. Few studies have considered the ability of tethered bis(polyhydroxyphenyl) compounds to inhibit microglial-driven inflammatory reactions in neurodiseases. Resveratrol and NDGA have been studied with respect to their ability to inhibit peroxidase enzymes specifically cyclo-oxygenase (COX) and lipoxygenase (LOX) in macrophage cells, but are not currently documented to antagonize microglial signaling pathways initiated by pro-inflammatory cytokine binding to cytokine-receptor tyrosine kinases (C-RTKs).
In sesame oil, lignans carrying a hydroxy group, that is, sesaminol, episesaminol, and sesamolinol, exhibit antioxidant activity (Osawa et al., 1985; Fukuda et al., 1985); however, sesamin as an antioxidant has not been evaluated clearly. The metabolized dicatechol products of sesamin in the liver after oral administration to rats were shown to be responsible for antioxidative properties observed Nakai et al. (2003). These antioxidative metabolites of sesamin have been isolated and structurally identified, but their anti-inflammatory action(s) has not been evaluated. <note, this isn't quite true, per my other post on sesmin>
Source: Method for using tethered bis(polyhydroxyphenyls) and O-alkyl derivatives thereof in treating inflammatory conditions of the central nervous system. Patent Appl. 20040014721 Jan 22, 2004. Citations referenced contained therein.
Sesalean
